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重大發現吔!大象低罹癌率!
Elephants appear to have a lower-than-expected rate of cancer, potentially related to multiple copies of the tumor suppressor gene TP53.
#1. TP53 gene: MedlinePlus Genetics
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, ...
#2. 7157 - Gene ResultTP53 tumor protein p53 [ (human)] - NCBI
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds ...
#3. TP53 Gene - Tumor Protein P53 - GeneCards
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds ...
TP53 ；, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53 ; TP53；, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53.
#5. Definition of TP53 gene - NCI Dictionary of Cancer Terms
A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death.
#6. Rare Mutation of TP53 Gene Leaves People at Higher Risk for ...
Mutations in the TP53 gene are the most commonly acquired mutations in cancer. The p53 protein, made by the TP53 gene, normally acts as the ...
#7. TP53 - Cellular tumor antigen p53 - Homo sapiens (Human)
Note. The gene represented in this entry is involved in disease pathogenesis · Description. A non-melanoma skin cancer affecting the head and neck. The hallmark ...
#8. Primary information of p53 gene - Bioinformatics.org
p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor ...
#9. Gene: TP53 (ENSG00000141510) - Summary - Homo_sapiens
Gene : TP53 ENSG00000141510 . Description. tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998].
#10. Why are there hotspot mutations in the TP53 gene in human ...
The p53 gene contains homozygous mutations in ~50–60% of human cancers. About 90% of these mutations encode missense mutant proteins that ...
#11. Entry - *191170 - TUMOR PROTEIN p53; TP53 - OMIM
Location Phenotype View Clinical Synopses Phenotype MIM number Inheritance Phenoty... 17p13.1 Bone marrow failure syndrome 5 618165 AD 3 17p13.1 Breast cancer, somatic 114480 3 17p13.1 Hepatocellular carcinoma, somatic 114550 3
#12. Understanding Your Positive TP53 Genetic Test Result
Everyone has two copies of the TP53 gene, which we randomly inherit from each of our parents. Mutations in one copy of the TP53 gene can increase the chance for ...
#13. Targeting mutant p53 for cancer therapy: direct and indirect ...
TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its ...
#14. Li-Fraumeni Syndrome | Cancer.Net
This condition is most commonly caused by a mutation (alteration) in a gene called TP53, which is the genetic blueprint for a protein called p53. The mutation ...
#15. TP53 (gene) | Radiology Reference Article | Radiopaedia.org
The TP53 gene, located on chromosome 17, is a tumor suppressor gene, responsible for the production of the p53 protein, a transcription ...
#16. TP53 Gene Mutation and Cancer Risk | Everyday Health
TP53 is a gene located on chromosome 17 that, when normal, stops cells from growing and dividing. You can inherit a TP53 mutation from your ...
#17. Mutant p53 in Cancer Progression and Targeted Therapies
TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority of mutations of p53 are missense mutations, ...
#18. TP53 - an overview | ScienceDirect Topics
TP53 is a gene found on chromosome 17 that codes for a 53-kDa protein involved in various aspects of the cell cycle, including cell death, response of cells ...
#19. TP53 - My Cancer Genome
Tumor protein p53 (TP53) is a gene that codes for a tumor suppressor protein, cellular tumor antigen p53. The protein regulates expression of genes involved ...
#20. tp53 - ZFIN Gene
Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); ...
#21. Adrenocortical Tumors: TP53 Gene
TP53 is a gene that codes for a protein called p53 that plays an important role in cell cycle control and functions as a tumor suppressor.
#22. Facts for people and families with a faulty TP53 gene (Li ... - eviQ
TP53 is a 'cancer protection' gene that helps to protect against many types of cancer. Everyone has two TP53 genes (one from their mother, and one from their ...
#23. Potential therapeutic targets of TP53 gene in the context of its ...
The TP53 gene was initially thought to be an oncogene, since mutant p53 protein was overexpressed in cancer cells. However, it was subsequently ...
#24. Overview of TP53 gene mutations
The TP53 (tumor suppressor protein 53 or p53) gene is located on chromosome 17. TP53 helps in the repair of damaged. DNA . Last updated March 19, 2022 ...
#25. Human Gene TP53 (ENST00000574684.1) from GENCODE ...
Description: tumor protein p53 (from HGNC TP53) RefSeq Summary (NM_001276697): This gene encodes a tumor suppressor protein containing transcriptional ...
#26. Dysfunction of the TP53 tumor suppressor gene in lymphoid ...
TP53 gene duplication is rare, and translocations involving the TP53 gene have not been reported. A total of 80.7% of p53 mutants have no transactivation ...
#27. TP53 (Tumour protein p53 (Li-Fraumeni syndrome))
Two international consortiums have reported the sequencing of more than 10.000 tumour genomes and confirmed that the TP53 gene is the most ...
#28. Large International Study Pinpoints Impact of TP53 Gene ...
TP53's normal function is to detect DNA damage and prevent cells from passing this damage on to daughter cells. When TP53 is mutated, the ...
#29. Gene test interpretation: TP53 - UpToDate
The TP53 gene encodes the tumor suppressor protein p53, which has been designated the guardian of the genome. It is responsible for much of ...
#30. TP53 Mutation Analysis | NeoGenomics Laboratories
The TP53 gene encodes the tumor suppressor p53. TP53 mutations are detected in at least 50% of all adult tumors and are generally associated with a poor ...
#31. TP53 | gene - Encyclopedia Britannica
…tumour suppressor genes (such as TP53, which encodes a protein known as p53) have been identified. The mutated form of TP53 has been ...
#32. The TP53 Gene and Its Role in Cancer - Verywell Health
A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth of tumors. A gene that has been coined "the guardian ...
#33. Association between TP53 gene deletion and protein ...
Tumor protein 53 (TP53) is a recognized tumor suppressor gene located on chromosome 17q13.1. The TP53 gene plays an important role in regulating ...
#34. TP53 Gene and Cancer Resistance in Elephants | JAMA
Apoptotic sensitivity was attributed to increased p53 protein levels. In Figure 6 in the article, levels were modestly elevated in elephant ...
#35. About the Li-Fraumeni Syndrome and TP53 Center
Li-Fraumeni syndrome (LFS) is a hereditary condition which is often associated with a pathogenic or likely pathogenic variant (mutation) in the TP53 gene ...
#36. RAS, BRAF, and TP53 Gene Mutations in Taiwanese ...
Chang YS, Chang SJ, Yeh KT, Lin TH, Chang JG*. RAS, BRAF, and TP53 Gene Mutations in Taiwanese Colorectal Cancer Patients. Onkologie 2013;36:719-24 (SCI ...
#37. p53 Gene | Summary - WhatIsBiotechnology.org
p53, also known as a tumour suppressor protein, is a gene that codes for a protein found in the nucleus of all cells in the body that helps regulate normal cell ...
#38. TP53 gene rs1042522 allele G decreases neuroblastoma risk
TP53 gene is located on the short arm of chromosome 17 and is 20 kb in humans. TP53 plays a role in the inhibition of apoptosis, genomic stability and ...
#39. A Novel TP53 Gene Mutation Sustains Non-Small Cell Lung ...
The TP53 gene is one of the most frequently mutated genes in cancer and is canonically known as a tumor suppressor. In fact, half of NSCLC ...
#40. CG-GENE-18 Genetic Testing for TP53 Mutations
The TP53 gene (also known as p53) located on chromosome 17 is a tumor suppressor gene. The protein product of the TP53 gene binds to cellular DNA and is ...
#41. Mutational Status of the TP53 Gene As a Predictor of ...
Purpose TP53 mutations have been described in chronic lymphocytic leukemia (CLL) and have been associated with poor prognosis in ...
#42. What is TP53? - News Medical
The TP53 is a gene that instructs the cell to produce tumor protein (p53) ; a vital transcription factor and tumor suppressor. P53 is known as the “guardian ...
#43. TP53 Hallmarks of Cancer - COSMIC
tumor protein p53. switch view. function summary. guardian of the genome [Pubmed] ; Molecule of the ...
#44. TP53 and Breast Cancer - Wiley Online Library
The TP53 gene (p53) is found altered in breast carcinomas in approximately 20–40% of all cases depending on tumor size and stage of the disease.
#45. TP53 Gene Mutations - Massive Bio
The p53 protein has a critical impact on the vital cycle of the cell. The p53 protein has a great effect on the cell's division and growth ...
#46. Evaluation of TP53 Gene Expression in Patients with ... - SciELO
To evaluate the expression of TP53 gene in patients with childhood cancer in northeastern of Santa Catarina, Brazil. Materials and Methods: Retrospectively, 282 ...
#47. The p53 Gene and Cancer - HHMI BioInteractive
It then explores one tumor suppressor gene, p53, and its role in cancer in more depth. Students learn about the structure of the protein ...
#48. TP53 Gene Set
Description, tumor protein p53|This gene encodes a tumor suppressor protein ... 2849 target genes of the TP53 transcription factor predicted using known ...
#49. Role of p53 Gene in Breast Cancer: Focus on Mutation ...
TP53 is a tumor suppressor gene which is commonly mutated in various cancers including breast cancer. Alterations in the gene lead to an altered expression ...
#50. TP53 FISH | Sonic Genetics
TP53 is one of the genes most frequently mutated in human cancer. Deletions of the TP53 gene can be identified in some patients with chronic lymphocytic ...
#51. The TP53 gene - The TP53 Website
The human TP53 gene organization as depicted over the past 20-plus years was simple: it produced a single transcript containing 11 exons encoding a single ...
#52. TP53 Gene - TP53 Mutant Clone - GenScript
Get the TP53 gene in an Expression-Ready Vector for your molecular biology studies by ordering a TP53 ORF Clone.
#53. Common genetic variants in the TP53 pathway and their ...
The TP53 gene is well known to be the most frequently mutated gene in human cancer. In addition to mutations, there are > 20 different coding region ...
#54. TP53 (基因)跟p53 (蛋白質)到底有什麼不同? - 基因叔叔- 痞客邦
TP53 是”基因”的名字 位在人類第17條染色體上的一個基因~~. 基因(Gene)是由核酸(Nucleic acid)組成的遺傳基本單位 核酸包括：核醣核酸(Ribonucleic acid)，簡稱為RNA及 ...
#55. Tp53 (tumor protein p53) - Rat Genome Database
Gene : Tp53 (tumor protein p53) Rattus norvegicus ... Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome ...
#56. TP53 copy number expansion is associated with the evolution ...
We found that the elephant genome encodes a single TP53 gene and 19 TP53 retrogenes, several of which are transcribed and translated in elephant ...
#57. Exploring the multiple roles of guardian of the genome: P53
It controls several genes that play a role in the arrest of the cell cycle, cellular senescence, DNA repair system, and apoptosis. P53 plays a ...
#58. The TP53 Database | ISB-CGC
The TP53 Database: knowledgebase and statistical tools for the analysis of TP53 gene variants in human cancers.
#59. UTSW study finds p53 gene plays second role in suppressing ...
The p53 gene has long been a focus of cancer research because of how often it's mutated in malignant tumors, covering more than half of all ...
#60. Genetic analysis of TP53 gene mutations in exon 4 ... - bioRxiv
molecular pathogenesis of EC considering TP53 gene from Sudanese population. ... immune-positive for p53 showed no mutations in p53 gene (exon4 and exon8).
#61. tp53 in All results | Search - EMBL-EBI
TP53 -target gene 5 protein. Homo sapiens(Reviewed). Cross References: Bioactive molecules (10) Protein expression data (9) Samples & ontologies ...
#62. Alterations of the TP53 Gene in Gastric and Esophageal ...
TP53 genes is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic ...
#63. An African-specific polymorphism in the TP53 gene impairs ...
The p53 tumor suppressor (TP53) holds the distinction of being the most frequently mutated gene in human cancer. Germline mutations in the TP53 ...
#64. Li-Fraumeni syndrome and the TP53 gene
Li Fraumeni syndrome is a rare, inherited cancer syndrome caused by mutations affecting the TP53 gene. It is associated with a very high risk of cancer ...
#65. TP53 | Cancer Genetics Web - CancerIndex
BACKGROUND: P53 is a key regulator of genomic stability and function, acting as a tumor suppressor protein. Our aim was to correlate P53 ...
#66. TP53 - Gene Detail - The Jackson Laboratory
Gene Description, TP53, tumor protein p53, is a tumor suppressor (PMID: 30562755) and ... TP53 germline mutations are common in Li-Fraumeni syndrome (PMID: ...
#67. TP53 Gene Somatic Mutation Pre-Analysis Cell Sorting, Varies
Determination of B-cell content and confirmation the presence of a clonal B-cell population evaluating chronic lymphocytic leukemia patients prior to TP53 ...
#68. TP53 Variant Curation Expert Panel | Clinical Genome Resource
The TP53 gene provides instructions for tumor protein p53 (or p53). This protein acts as a tumor suppressor, regulating cell division by ...
#69. No mutation detected in five hot spot codons of the TP53 gene ...
Most of them found a lower prevalence of TP53 gene mutation than p53 protein expression in head and neck cancer. The association between p53 expression and TP53.
#70. The TP53 gene homepage - Global Variome shared LOVD
General information. Gene symbol, TP53. Gene name, tumor protein p53. Chromosome, 17. Chromosomal band, p13.1. Imprinted, Unknown.
#71. High-throughput amplicon scanning of the TP53 gene in ...
coding region of the TP53 gene (exons 2–11) was PCR-amplified from breast cancer samples and scanned by high-resolution fluorescent melting curve analyses ...
#72. ERIC recommendations for TP53 mutation analysis in chronic ...
In chronic lymphocytic leukemia (CLL), TP53 gene defects, due to deletion of the 17p13. 76 locus and/or mutation(s) within the TP53 gene, are associated ...
#73. p53 gene: The Guardian of the genome. functions, regulation ...
This Short tutorial explains p53 Gene. click https://www.youtube.com/watch?v=tuwogQmcAps for understanding the Retinoblastoma Gene****Follow ...
#74. Teacher Background on p53 Tumor Suppressor Protein - OHSU
symbol is TP53. TheTP53 gene codes for the TP53 (p53) protein which acts as a tumor suppressor and works in response to DNA damage to orchestrate the repair ...
#75. Alterations in TP53 gene – Implications in Tumorigenesis ...
In most cases, TP53 mutation is accompanied by loss of heterozygosity (LOH) on 17p resulting in the complete absence of the wild-type TP53 gene. Those diffuse ...
#76. TP53 Gene Mutations in Prostate Cancer Progression
The TP53 tumor suppressor gene is one of the most frequently mutated genes in human malignancies (5). However, the mutation frequency of TP53 in PCa has a ...
#77. Association of TP53 gene polymorphisms with susceptibility of ...
TP53 is a tumor suppressor gene which plays an important role in cell cycle control and apoptosis. A functionally normal p53 (protein coded by ...
#78. TP53 Mutational Status and Prediction of Benefit from ...
In colon cancer, mutations in the TP53 gene are present in more than 30% of tumors. We found that the most commonly used postoperative ...
#79. The expression of the TP53 gene in various classes of acute ...
A genetic mutation in TP53 (Tumor Protein 53) gene is detected in most malignancies and considered a key element in the determination of treatment planning ...
#80. IARC: Home
Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers. 14 Feb 2023 · Age-Specific Prevalence of Anal and Cervical Human ...
#81. p53 (TP53, Tumor Protein p53) Gene Mutation Analysis
p53 (TP53, Tumor Protein p53) Gene Mutation Analysis. Li-Fraumeni Syndrome. Germline (heritable) mutations in the p53 gene1 predispose individuals to various ...
#82. TP53 | Homo sapiens gene - Alliance of Genome Resources
Species: Homo sapiens; Symbol: TP53; Name: tumor protein p53; Synonyms. antigen NY-CO-13; BCC7. Show All 20. Biotype: protein coding gene ...
#83. BIALLELIC TP53 GENE MUTATIONS DUE TO COPY ...
BIALLELIC TP53 GENE MUTATIONS DUE TO COPY-NEUTRAL LOSS OF HETEROZYGOSITY AND MONOALLELIC MUTATIONS IN ABSENCE OF 17P DELETION OCCUR IN CLL WITH COMPARABLE ...
#84. Identification of Highly Frequent TP53 Germline Variations in a ...
These results shall contribute in delineating the genetic component of head and neck cancers. Introduction. TP53 is a tumor suppressor gene. Its ...
#85. Polymorphism in a tumor suppressor (TP53) gene (G215C ...
About 14 SNPs have been identified in the wild-type TP53 gene, which could change the function of the p53 protein. One of the most common SNPs of the TP53 ...
#86. All transcripts active for the TP53 gene -
LOVD - Leiden Open Variation Database. TP53 (tumor ...
#87. TP53 (17p13) Orange + Copy Control 17 Green FISH Probe
The p53 tumor suppressor protein is encoded by the TP53 gene located on chromosome 17p13. Under normal conditions the TP53 gene functions as a safeguard in ...
#88. The Guardian of the Genome the TP53 Gene - KromaTiD
p53-genep53 bound to DNA p53 prevents cancer formation and acts as a guardian of the genome. Mutations in the p53 gene contribute to about ...
#89. Lozano Lab, p53 Gene Research | MD Anderson Cancer Center
Mutation of the p53 gene is a critical event in the elaboration of many tumors of diverse origin. The p53 protein is activated in response to DNA damage, ...
#90. TP53 Gene Analysis in Li-Fraumeni Syndrome - GeneDx
TP53 Gene Analysis in Li-Fraumeni Syndrome ... well as leukemia, lymphoma, and neuroblastomas.1,2 The risk for males and females with a germline TP53.
#91. Clinical implications of TP53 mutations in a southeast asian ...
Background: TP53 gene is a tumour suppressor gene located in the short arm of chromosome 17. TP53 plays a pivotal role in maintaining ...
#92. Li-Fraumeni Syndrome
It is important to note that not everyone with a TP53 gene mutation will necessarily develop cancer, but the risks are substantially higher ...
#93. Pre-cancer Diagnosis via TP53 Gene Mutations by Using ...
PDF | On Jun 1, 2019, Dina Y. Mikhail published Pre-cancer Diagnosis via TP53 Gene Mutations by Using Bioinformatics & Neural Network | Find ...
#94. R337H mutation of the TP53 gene as a clinical marker in ...
The germline R337H mutation of the TP53 gene has been associated with the development of many tumor types. This systematic review of literature investigated ...
#95. TP53 Gene Somatic Mutation Pre-Analysis Cell Sorting, Varies
TP53 gene variant status in CLL has emerged as the single most predictive tumor genetic abnormality associated with adverse outcome and poor response to ...
#96. Reactivating p53 in breast cancer | OTT - Dove Medical Press
Role of Reactivating Mutant p53 Protein in Suppressing Growth and Metastasis of Triple-Negative Breast Cancer ... Abstract: Tumor suppressor p53 ...
#97. TP53 gene interaction network - Target Explorer
Name: tumor protein p53, Symbol: TP53, Category: gene, Type: transcription regulator, Synonyms: bbl, BCC7, bfy, bhy, brp53, drp53, etID22686.5, fb40d06, ...
#98. Adenovirus-based Transfer of Wild-Type p53 Gene Increases ...
The p53 tumor suppressor gene product is known to be active in mediating radiation-induced G1-S cell cycle arrest and apoptosis in a number of normal cell ...
tp53 gene 在 p53 gene: The Guardian of the genome. functions, regulation ... 的推薦與評價
This Short tutorial explains p53 Gene. click https://www.youtube.com/watch?v=tuwogQmcAps for understanding the Retinoblastoma Gene****Follow ... ... <看更多>